个人简介
刘厚赫，讲师，男，1992年2月，2022年毕业于广州医科大学，获医学博士学位，硕士研究生导师。研究方向小分子光敏的合成、医用辅料的开发。
承担的主要教学、科研项目:
(1)米兰体育官网入口高层次人才（博士）科研启动基金，含硒吩噻嗪光敏剂的合成、表征及其光动力活性的评价，2022/8-2028/8，在研，主持
(2) 国家自然科学基金委员会, 面上项目, 82170467, 跨膜蛋白FLRT2通过诱导单核-巨噬细胞分化加重动脉粥样硬化的作用及机制, 2022-01-01 至 2025-12-31, 55万元, 在研, 参与
(3) 国家自然科学基金委员会, 面上项目, 22175046, 基于限域电子贴附解离的新型乏氧肿瘤放射动力学疗法, 2022-01-01 至 2025-12-31, 61万元, 在研, 参与
(4) 国家自然科学基金委员会, 青年科学基金项目, 81803463, 基于细胞毒性药物5-FU在肿瘤局部产生原理的前药代谢酶基因CDUPRT脂质体用于乳腺癌靶向化疗, 2019-01-01 至 2021-12-31, 21万元, 结题, 参与
代表性学术成果:
论文：
1.Liu H, Jiang Y, Wang Z, Zhao L, Yin Q, Liu M. Nanomaterials as carriers to improve the photodynamic antibacterial therapy. Front Chem. 2022 Nov 25;10:1044627.
2: Liu H, Yang F, Chen W, Gong T, Zhou Y, Dai X, Leung W, Xu C. Enzyme-Responsive Materials as Carriers for Improving Photodynamic Therapy. Front Chem. 2021 Nov;9:763057.
3: Zhou Y, Deng W, Mo M, Luo D, Liu H, Jiang Y, Chen W, Xu C. Stimuli-Responsive Nanoplatform-Assisted Photodynamic Therapy Against Bacterial Infections. Front Med (Lausanne). 2021 Sep;8:729300.
4: Liu H, Quan Y, Jiang X, Zhao X, Zhou Y, Fu J, Du L, Zhao X, Zhao J, Liang L, Yi D, Huang Y, Ye G. Using Polypeptide Bearing Furan Side Chains as a General Platform to Achieve Highly Effective Preparation of Smart Glycopolypeptide Analogue-Based Nano-Prodrugs for Cancer Treatment. Colloids Surf B Biointerfaces. 2020 Oct;194:111165.
5: Liu H, Yao J, Guo H, Cai X, Jiang Y, Lin M, Jiang X, Leung W, Xu C. Tumor Microenvironment - Responsive Nanomaterials as Targeted Delivery Carriers for Photodynamic Anticancer Therapy. Front Chem. 2020 Sep;8:758.
6: Zhao L, Zheng R, Chen H, Liu L, Zhao X, Liu H, Qiu X, Yu X, Cheng H, Li S. Self-Delivery Nanomedicine for O2-Economized Photodynamic Tumor Therapy. Nano Lett. 2020 Mar;20(3):2062-2071.
7: Jiang X, Lin M, Huang J, Mo M, Liu H, Jiang Y, Cai X, Leung W, Xu C. Smart Responsive Nanoformulation for Targeted Delivery of Active Compounds From Traditional Chinese Medicine. Front Chem. 2020 Dec;8:559159.
8: Huang H*, Liu H*, Zhou H, Liang Z, Song D, Zhang Y, Huang W, Zhao X, Wu B, Ye G, Huang Y. Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis. Drug Des Devel Ther. 2019 Mar;13:881.（*共同第一作者）
9. Yu M, Zhong S, Quan Y, Liu H, Zhong J, Jiang X, Ma C, Huang Y. Synthesis of AIE polyethylene glycol-block-polypeptide bioconjugates and cell uptake assessments of their self-assembled nanoparticles. Dyes and Pigments. 2019 Jan;170:107640.
10. Liang Z*, Liu H*, Su N, Song D, Zhang Y, Huang H, Zheng J, Zhong C, Ye G. Study of the Deformation/Interaction Model: How Interactions Increase the Reaction Barrier. J. Chem. 2018 Jan;2018:3106297.（*共同第一作者）
11: Zhang Y, Song D, Huang H, Liang Z, Liu H, Huang Y, Zhong C, Ye G. Minimally Invasive Hemostatic Materials: Tackling a Dilemma of Fluidity and Adhesion by Photopolymerization in situ. Sci Rep. 2017 Nov;7(1):15250.
12. Zhang Y, Huang H, Liang Z, Liu H, Yi L, Zhang J, Zhang Z, Zhong C, Huang Y, Ye G. Microscopic progression in the free radical addition reaction: modeling, geometry, energy, and kinetics. J Mol Model. 2017 Mar;23(3):73.
13. 刘厚赫, 王振, 刘兆明, 时亚博, 高俊鹏. 正交试验优选昆仑雪菊总皂苷的提取工艺. 中国药房. 2015;26:4415.
专利：
[1]一种噻吩-吩噻嗪化合物及其合成方法和在制备光治疗药物中的应用. 专利号202310334638.
电子邮箱：liuhouhe@lyu.edu.cn