个人简介：
郝春香，副教授，女，1989年1月生， 2016年毕业于法国国家医药卫生研究院与雷恩第一大学，获博士学位，硕士生导师。专业为生物信息学。主要研究领域为药理学及表观遗传学。长期从事高通量基因组学、特别是 ChIP-seq、RNA-seq 的生物医学信息、和系统生物学研究,具有生物医学工程、计算机和数学的交叉学科背景。近年来参与完成的研究成果相继发表在 Nucleic Acids Research, Clinical Epigenetics, Bioinformatics,等国际权威刊物上。先后主持包括国家自然科学基金、山东省自然科学基金等在内的多项科研项目。
承担的主要科研项目:
1. 国家自然科学基金，精子中组蛋白修饰H3K4me3在跨代遗传中的作用，2019/01-2021/12，21万元，结题，主持
2. 山东省自然科学基金，癌细胞特异性组蛋白适体的研究，2017/08-2019/12，5万元，结题，主持
代表性学术成果:
论文：
Nan Hao, Huawei Xin, Xiaowei Shi, Jie Xin, Haijuan Zhang, Shaofen Guo, Zhen Wang, Chunxiang Hao*. Paternal reprogramming-escape histone H3K4me3 marks located within promoters of RNA splicing genes. Bioinformatics. 2021 Apr 15; 37(8): 1039–1044.
Chunxiang Hao, Aurore Gely-Pernot, Christine Kervarrec, Melissa Boudjema, Emmanuelle Becker, Pavel Khil, Sergei Tevosian, Bernard Jégou, and Fatima Smagulova. Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice. Nucleic Acids Research. 2016;44(20):9784-802.
Zhiyi Zhang, Juan Wang Bingying Liu, Yu Liu, Xiaowei Shi, Wenli Li, Huawei Xin, Jie Xin, Chunxiang Hao*. Anticancer effects of herbal medicines in pancreatic ductal adenocarcinoma through modulation of steroid hormone response proteins. Sci Rep. 2022 Jun 14;12(1):9910. doi: 10.1038/s41598-022-14174-1.
Yunchao Zhang, Lihui Liang, Yueshang Wang, Yulei Cui, Chunxiang Hao*, Huawei Xin, Anti-cancer effects of Shenqishiyiwei granules in gastric cancer are mediated via modulation of the immune system, Journal of Functional Foods, Volume 98,2022,105280,ISSN 1756-4646,https://doi.org/10.1016/j.jff.2022.105280.
Shereen Cynthia D’Cruz#, Chunxiang Hao#, Martin Labussiere, Vicente Mustieles, Carmen Freire, Louis Legoff, Laura Magnaghi-Jaulin, Alicia Olivas-Martinez, Andrea Rodriguez-Carrillo, Christian Jaulin, Arthur David, Mariana F. Fernandez & Fatima Smagulova. Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro data. Clin Epigenetics. 2022 Dec 26;14(1):186. doi: 10.1186/s13148-022-01408-2. PMID: 36572933; PMCID: PMC9793539. (共同第一作者)
Yu Liu*, Chunxiang Hao*, Guangyang Wang, Qian Li, An Shao. Exogenously spermidine alleviates damage from drought stress in the photosystem II of tall fescue.Plant, Soil and Environment.2021 67: 558–566.https://doi.org/10.17221/236/2021-PSE. (通讯作者)
Yun-Guo Liu#, Chunxiang Hao#, Shaoying Shi, Kaiyun Dang, Xiaokui Huang, Zhilong Zhao, Xiaowei Shi, Transcriptome analysis of the immunomodulation by Arctium lappa L. polysaccharides in the Chinese mitten crab Eriocheir sinensis against Aeromonas hydrophila. Aquaculture. Volume 534, 15 March 2021, 736255. #Contributed equally. (共同第一作者)
Aurore Gely-Pernot#, Chunxiang Hao#, Louis Legoff, Luc Multigner, Shereen Cynthia D’Cruz, Christine Kervarrec, Bernard Jégou, Sergei Tevosian, and Fatima Smagulova. Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males. Scientific Reports. 2018 Jul 6;8(1):10274. doi: 10.1038/s41598-018-28670-w. #Contributed equally. (共同第一作者)
Aurore Gely-Pernot#, Chunxiang Hao#, Emmanuelle Becker, Igor Stuparevic, Christine Kervarrec, Frédéric Chalmel, Michael Primig, Bernard Jégou, and Fatima Smagulova. The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine. BMC Genomics, 2015, 16(1): 885. #Contributed equally. (共同第一作者)
Aurore Gely-Pernot, Souhila Saci, Pierre-Yves Kernanec, Chunxiang Hao, Frank Giton, Christine Kervarrec, Sergei Tevosian, Severine Mazaud-Guittot & Fatima Smagulova. Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice. Sci Rep. 2017 Jun 14;7(1):3526.
Fabrice G. Petit, Christine Kervarrec, Soazik P. Jamin, Fatima Smagulova, Chunxiang Hao, Emmanuelle Becker, Bernard Jégou, Frédéric Chalmel Michael Primig. Combining RNA and protein profiling data with network interactions identifies genes associated with spermatogenesis in mouse and human. Biol Reprod, 2015, 92(3): 71.
Zhang, L., C. Hao, X. Shen, G. Hong, H. Li, X. Zhou, C. Liu and Z. Guo (2013). "Rank-based predictors for response and prognosis of neoadjuvant taxane-anthracycline-based chemotherapy in breast cancer." Breast Cancer Res Treat 139(2): 361-369.
Zou, J., C. Hao, G. Hong, J. Zheng, L. He and Z. Guo (2012). "Revealing weak differential gene expressions and their reproducible functions associated with breast cancer metastasis." Comput Biol Chem 39: 1-5.
Zhang, L., S. Li, C. Hao, G. Hong, J. Zou, Y. Zhang, P. Li and Z. Guo (2013). "Extracting a few functionally reproducible biomarkers to build robust subnetwork-based classifiers for the diagnosis of cancer." Gene 526(2): 232-238.
Shen, X., S. Li, L. Zhang, H. Li, G. Hong, X. Zhou, T. Zheng, W. Zhang, C. Hao, T. Shi, C. Liu and Z. Guo (2013). "An integrated approach to uncover driver genes in breast cancer methylation genomes." PLoS One 8(4): e61214.
电子邮箱：chunxianghao@outlook.com