
个人简介:
王丹丹,教授,女,1987年1月生,2017年毕业于中国科学院大学,获博士学位,硕士生导师。研究方向为药物分析。招生方向:化学(学硕)、生物与医药(专硕),招生联系方式13641758223(微信同号)。
承担的主要教学、科研项目:
国家自然科学基金委,面上项目,82073813,胆红素代谢酶UGT1A1诱导剂高效筛选体系的构建与应用,2021-01至2024-12,55万,主持;
国家自然科学基金委,青年项目,81703604,人羧酸酯酶与配体相互作用规律及其分子机制研究,2018-01至2020-12,20.1万,主持;
中国博士后科学基金,特别资助,2018T110406,基于高内涵细胞成像的CE1活性筛选模型的构建及其应用,2018-06至2019-06,15万,主持;
中国博士后科学基金,面上项目,2017M621520,基于CE1的天然降血脂药物高效筛选方法的构建及其应用,2017-10至2019-05,5万,主持;
上海中医药大学青年教师培养资助计划,基于CE1的天然降血脂药物高效筛选方法的构建及其应用,5万,主持。
代表性学术成果:
论文:
Qiang Jin, JingJing Wu, Yue Wua Hongxin Li, Moshe Finel, Dandan Wang*, Guangbo Ge*. Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives. Acta Pharmaceutica Sinica B, 2022; 12(3): 1068e1099.
Qiang Jin, Zan Li, Meng-Jie Zhang, Wen-Cai Liu, Li-Wei Zou, Hua Sui, Dan-Dan Wang*, Qing-Feng Tang*, Guang-Bo Ge*. Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate. Chemico-Biological Interactions, 2022(368): 110197.
Wang DD#, Qian XK#, Li HX, Jia GH, Jin Q, Luan X, Zhu YD, Wang YN, Huang J, Zou* LW, Ge GB*, Yang L*. Sensing and imaging of exosomal CD26 secreted from cancer cells and 3D colorectal tumor model using a novel near-infrared fluorogenic probe. Materials Science & Engineering C, 2021; 130: 112472.
Wang DD#, Zou LW#, Jin Q, Guan XQ, Yu Y, Zhu YD, Huang J, Gao P, Wang P, Ge GB*, Yang L*. Bioluminescent sensor reveals that carboxylesterase 1A is a novel endoplasmic reticulum-derived serologic indicator for hepatocyte injury. ACS Sensors 2020; 5, 7:1987–1995.
Zhu YD, Pang HL, Zhou QH, Qin ZF, Jin Q, Finel M , Wang YN, Qin WW, Lu Y, Wang DD*, Ge GB*. An ultra-sensitive and easy-to-use assay for sensing human UGT1A1 activities in biological systems. Journal of Pharmaceutical Analysis 2020; 10: 263-270.
Zhu YD, Guan XQ, Chen J, Peng S, Finel M, Zhao YY, Wang RM, Bi HC, Lei M *, Wang DD*, Ge GB*. Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARalpha and PPARgamma. Frontiers in Pharmacology 2020, 11, 628314.
Xue LJ, Qian XK, Jin Q*, Zhu YD, Xiaoyu Wang, Dandan Wang*, Guangbo Ge, Ling Yang. Construction and application of a high content analysis for identifying human carboxylesterase 2 inhibitors in living cells system. Analytical and Bioanalytical Chemistry, 2020,412: 2645–2654.
Song PF#, Zhu YD#, Ma HY, Wang YN, Wang DD*, Zou LW*, Ge GB, Yang L. Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1. Fitoterapia 2019; 137: 104199-104206.
Wang DD#, Zou LW#, Jin Q, Hou J, Ge GB*, Yang L, Human carboxylesterases: a comprehensive review. Acta Pharmaceutica Sinica B 2018;8,5:699–712.【ESI 高被引论文】
Wang DD#, Zou LW#, Jin Q, Hou J*, Ge GB*, Yang L, Recent progress in the discovery of natural inhibitors against human carboxylesterases, Fitoterapia 2017; 117: 84-95. 【ESI 高被引论文】
Lei W#,Wang DD#,Dou TY,Hou J,Feng L,Yin H,Luo Q,Sun J,Ge GB*, Yang L, Assessment of the inhibitoryeffects of pyrethroids against human carboxylesterases, Toxicology and Applied Pharmacology 2017; 321:48-56.【ESI 高被引论文】
Wang DD, Jin Q, Zou LW, Hou J, Lv X, Lei W, Cheng HL, Ge GB*, Yang L*. A bioluminescent sensor for highly selective and sensitive detection of human carboxylesterase 1 in complex biological samples, Chemical communications 2016; 52: 3183-3186.
专利:
杨凌、邹立伟、葛广波、王丹丹、王平、于洋、杜逊甫,人羧酸酯酶1的生物发光探针底物及其制备方法与应用,申请日期:2016-03-03,授权日期:2019-02-01,中国,专利号:ZL201610119590.9;
邹立伟,王丹丹,钱星凯,张静,杨凌,葛广波,金强,宋培放,1-环己基吡唑啉酮类羧酸酯酶1抑制剂及其应用,申请号:202011182707.0,申请日期:2020-10-29;授权公告日:2023-02-28;授权公告号:CN 112279813 B;专利号:ZL 2020 1 1182707.0
邹立伟,王丹丹,钱星凯,张静,杨凌,葛广波,金强,宋培放,1-环己基吡唑啉酮类羧酸酯酶1抑制剂及其应用,申请号:202011182707.0,申请日期:2020-10-29;授权公告日:2023-02-28;授权公告号:CN 112279813 B;专利号:ZL 2020 1 1182707.0
